Developmental, Behavioral, Cellular and Molecular evaluation of a embryo-fetal and juvenile toxicity induced by the chronic exposure during gestational and lactational phases to a mixture of the 6 NDL-PCB indicators in a mouse model
“The raise of anthropogenic activities has led to a large release of various chemicals in the environment. These pollutants can affect the animal and human health via food chain contamination. Actually, epidemiological studies reveal a significant raise of mental and neurological disorders among children such as autism or kinetic disorders. Environmental pollutants are highly suspected to induce such pathologies when exposition occurs at early stages. Thus, it becomes extremely relevant to study their mechanisms of action through some interdisciplinary approaches, in functional and molecular biology, in genomic and transcriptomic analyses. Our project, divided into eleven tasks, aims to develop such an approach to increase our knowledge on some ubiquitous pollutants. This project has already been submitted to a previous evaluation (CES 2010). Thus, the criticisms and recommendations of the experts have been carefully taken into account in this new version. It also joins the perspectives of PNSE researches, evenly focuses on risks induced by food contaminants such as ALIA, ANSES and also REACH program objectives (CD 2I).
This project would lead to the elaboration of a European consortium, dedicated to the assessment of the neurotoxic risk. The choice of the 6 Non-Dioxin-Like PolyChloroBiphenyls indicators (6 NDL-PCBi) is motivated by their strong occurrence in food matrices as well as the great rarity of the results in literature relative to their neurotoxicity (AFSSET, AFSSA-ANSES, EFSA). The exposure to these xenobiotics is incontestable, since they are indicators of the food chain contamination for the NDL-PCBs sub-family, and secondly, they are highly detected in several human tissues, including brain. We wish to investigate the neurotoxicity of a relevant mixture of the 6 NDL-PCBi, which proportions of each congener and doses are carefully argued. It is divided in two parallel approaches: Read More ….“
For more informations:
The Neurodevetox Project Coordinator:
Pr. Rachid SOULIMANI
Neurotoxicology and development
BP 4102, 57040 Metz cedex 01, France ;